Software

Client Testimonial

I suppose I am the toxicological pathologist that has used Roelee for the longest period, over 25 years so far. During that time, I have used it almost daily and I have also been fortunate enough to have had some input into its development.

Having witnessed the inception of many pathology computer programs in the early 1980s, Roelee has always stood apart from the others for the difference in its basic approach to the task and its immense in-built analytical power and sheer flexibility.

Most rival programs have concentrated on an easy-to-use interface for the pathologist to enter data and then struggled to provide adequate reporting and analytical features. Roelee, however, was designed to analyse and report the data from the outset, at the initial cost of making the data entry interface a little less intuitive. Although it required a slight conceptual adjustment, at first, I know that I could never revert to something more limited in scope. By analogy, I suppose it is the difference between an upright piano and a church organ, the tunes may be similar but the overall impact is incomparable.

The development of software for conducting peer review from data generated on many other systems is an almost unique feature of Roelee and one that I have used since its inception; in fact I asked them to try to do it! Because of their open approach, the problems that initially bedevilled the programming were always explained by the two Johns (often in words of one syllable), so that we could achieve the best result and, this feature has become more refined to enable me to use it with confidence all over the world.

During the development of the program, there have been issues of new technology, user-friendliness, security, 21 CFR Part 11, new analytical techniques and report formats and the challenges of the ever-changing computer operating systems imposed upon us by Bill Gates and his cronies. Through all of that, Peter and the two Johns have coped with all the trials and tribulations with great energy, innovation, humour and above all rapidity. I know of no other software provider that can assess, analyse and rectify problems in such a short period, often minutes or hours.

The generation of an expanding user group has seen more strides forward, with enhancements and improvements that have allowed this cost-effective, powerful program to thrive whilst most of the early rivals have withered on the vine.

Kevin Isaacs MA, VetMB, MRCVS, FRCPath

Introduction:

RoeLee is developed, enhanced and supported by the statistical and computing specialists at Roelee Statistics and Computing Ltd with advice from experienced pathologists. Since its first release in 1984 new features have been added continuously and is now used worldwide by major corporations and individual pathologists alike.

  • A Histopathology and Necropsy system for Windows XP, Windows 7, Windows 8 & Windows 10.
  • Excellent data entry, reporting and statistical analysis facilities.
  • A powerful Peer Review System is available to accompany RoeLee. The Peer Review system can be used as a standalone application to work alongside your existing system
  • Import and analyse data from other major histopathology systems  such as PROVANTIS, PATHDATA,  XYBION  etc
  • Export data in many formats including  FDA electronic submission via  SAS transport files and SEND format
  • FDA compliance and SEND format submissions.    
    Recently the FDA have become more concerned about the use and submission of electronic records and have issued guidelines in 21 CFR Part11 and SEND file definitions. We have taken these FDA guidelines on board and the latest version of RoeLee will help your company achieve 21 CFR Part11 compliance.    .

At RoeLee statistics we aim to give an all-round service to our clients. Help on using RoeLee, on statistical problems and on computing are all just a phone call away. We also carry out analyses of pre-clinical and clinical data, using RoeLee for many major companies.

Histopathology        More info on RoeLee Histopathology    

Entry of histopathology data is made simple and consistent by using grading systems to classify findings. Grading systems, findings and organs can be specified in a user-specific lexicon, or set up as encountered during data entry. The abbreviations used for these are chosen by the user.

RoeLee includes:-

  • Blind numbering
  • Tumour coding: benign, malignant, metastases or multi-centric
  • Sex-specific and/or paired organs
  • Factors contributory to death and predominant pathology
  • Data validation against standard or client-specified criteria.

Necropsy       More info on RoeLee Necropsy    

RoeLee provides for input and reporting of necropsy data. This includes:-

  • Multi-user data entry
  • Organ weights transferred directly from balance to system
  • Production of slide preparation forms
  • Reporting of lesions grouped by topography.

The necropsy data may be accessed during slide reading:-

  • Organs missing or abnormal at necropsy are highlighted on histopathology screens
  • Full necropsy details can be viewed during histopathology data entry
  • Validation of histopathology data against necropsy data
  • Joint reports of necropsy and histopathology findings.

Reporting      More info on RoeLee Reports and Tables    

All the standard necropsy and histopathology reports and many more exist in RoeLee:-

  • Reports which meet the requirements of the FDA, EPA and Japanese MAFF
  • Export data in SEND format
  • Correlations between necropsy and histopathology findings
  • Factors contributory to death
  • Histograms and Plots including Kaplan-Meier.

RoeLee allows the user to:-

  • Select animals by organ, finding, tumour type and/or animal number
  • Report a whole study at the push of a button using 'Command Files' tailored to the client's requirements
  • Output to any combination of screen, file and printer.
  • Control page layout - headings, footnotes, table and page numbers, margins and tabs

Statistical Analysis     More info on RoeLee Statistical Analysis    

RoeLee provides all the major statistical tests required. The user can control many factors including:-

  • Sexes - combined, separate, one sex only
  • Tumours - inclusion/exclusion of non-neoplastic findings, primary tumours, multicentrics, metastases
  • Selection of animals
  • Age-adjustment and stratification
  • Reporting of missing values
  • Comparisons - pair-wise, trend, heterogeneity
  • Transformations of data to give new data fields for analysis and reporting.

RoeLee can also be used to summarise Historical Control data and to analyse In-life data. The flexibility of the system also allows recording and analysis of data from clinical trials.

Security

RoeLee has many security features:-

  • Access control by passwords
  • Levels of access
  • Audit trail
  • Data integrity following system crashes.
  • FDA 21CFR Part 11 compliance.   Our thoughts on RoeLee and 21 CFR Part11
    Recently the FDA have become more concerned about the use and submission of electronic records and as such have issued guidelines in 21 CFR Part11. We have taken these FDA guidelines on board and a new version RoeLee 3.1 is available which will help your company achieve 21 CFR Part11 compliance.

Interfaces

RoeLee can:-

  • Import and analyse data from other major histopathology systems
    • ACOPAT
    • DATATOX
    • PATHDATA
    • PLACES
    • XYBION
  • Export data in a number of formats, including Rich Text Format(RTF), for inclusion in the client's preferred reporting software
  • Export data in the format required for reporting to the FDA including SAS export format.
  • Interfaces to and from ROELEE can be produced quickly to meet the client's special requirements.

Interfaces have also been written for systems such as SPSS and PARADOX. These interfaces give users the power to use ROELEE to analyse all the conditions in a study using quick, powerful statistical functions specially designed for this type of study. Users can also use the ROELEE tabulations and reporting facilities to get the special reports needed for regulatory authorities which may not be available in their own data entry systems. With their wide experience of writing such interfaces, we are confident of dealing with data from almost all computer data entry systems.